4. Thyroid Hormone and Lipid Metabolism: Novel Thyroid Hormone Receptor β1 Selective Thyroid Hormone Analogs

Lipid Metabolism and Thyroid Hormone : a Review

Thyroid hormone , secreted by thyroid gland have a profound effects on the lipid metabolism. It exerts its action mainly by its genomic action. It diffuses from the extracellular fluid across the plasma membrane and go directly into the nucleus. The cognate receptor binds to the thyroid hormone response element [TRE].It regulates the gene expression of key enzymes involved in lipid metabolism b...

Thyroid Hormone Metabolism

This book contains a collection of 26 papers that were presented at an International Symposium in Glasgow, Scotland, August, 1974. It is divided into two sections entitled "Metabolism and Binding" (15 papers) and "Thyroid Hormone Function in Clinical Investigation" (11 papers). The first section begins with an authoritative review by J. Robbins on the structure and function of serum thyroxine-t...

Metabolism of Thyroid Hormone

Thyroid hormone is indispensable for normal development and metabolism of most cells and tissues. Thyroid hormones are metabolized by different pathways: glucuronidation, sulfation, and deiodination, the latter being the most important. Three enzymes catalyzing deiodination have been identified, called type 1 (D1), type 2 (D2) and type 3 (D3) iodothyronine deiodinases. D1 and D2 have outer ring...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone

Thyroid Stimulating Hormone Receptor

Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role in tumor growth, which is initiated by sev...